Iran denounced Israel’s heavy bombardment on Friday as a “declaration of war,” following a lethal attack that targeted approximately 100 major targets, including nuclear installations and senior military officers. The United States, while avoiding association with the operation, threatened Iran with tougher penalties if it does not accept a nuclear agreement.

The Israeli army said it had killed several top generals, including the entire command structure of the Revolutionary Guard’s air force. Iran’s highest-ranking military officer, Chief of Staff Mohammad Bagheri, and Revolutionary Guards commander Hossein Salami were among the reported fatalities.

Iran’s Supreme Leader Ayatollah Ali Khamenei pledged a “bitter and painful” reprisal, with Foreign Minister Abbas Araghchi and President Masoud Pezeshkian making threatening warnings of reprisal. In turn, President Trump called on Tehran to make a deal, threatening “more death and destruction” if not.

The Israeli attacks, which had the aim of thwarting Iran’s nuclear aspirations, had targeted the Natanz uranium enrichment plant. Israeli Prime Minister Benjamin Netanyahu had said the operation would continue “as long as needed,” based on intelligence that Iran was approaching the “point of no return” in its nuclear program.

Iran retaliated by launching about 100 drones, most intercepted before reaching Israeli airspace. Jordan also confirmed downing drones that breached its territory. While the US emphasized its non-involvement, it cautioned Iran against targeting American assets.

Civilian casualties were reported in Tehran, with 95 wounded and infrastructure damage visible across the capital. The situation has paralyzed daily life, disrupted air travel, and sparked public fear.

With diplomatic attempts in the balance, concerns now hover over the future of planned nuclear talks in Oman. As tensions escalate, world markets responded sharply oil prices climbed and stock markets fell, highlighting the escalating risk of wider regional escalation.